phenobarbital will minimize the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Talk to your health practitioner In case you have questions on sorts of birth Manage that can be just right for you. For those who or your associate become pregnant even though using bortezomib or for 7 months immediately after your final dose, connect with your medical doctor immediately.
Acute respiratory distress syndrome (ARDS) and acute diffuse infiltrative pulmonary illness of unknown etiology for example pneumonitis, interstitial pneumonia, lung infiltration have transpired
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Contraindicated (1)bortezomib improves amounts of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with potent or reasonable CYP2D6 inhibitors, minimize eliglustat dose from eighty four mg BID to 84 mg once day by day in extensive and intermediate metabolizers; eliglustat is contraindiated if potent or reasonable CYP2D6 inhibitors are presented concomitantly with powerful or moderate CYP3A inhibitors.
sparsentan will lessen the extent or outcome of bortezomib by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and cuts down efficacy relevant to these substrates.
Amyloidosis: People with amyloidosis also needs to get bortezomib therapy with good caution as you'll find studies that the use of bortezomib can lead to excess protein accumulation in several organs.
bortezomib will enhance the stage or effect of lemborexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. 3'-cGAMP sodium Modify Therapy/Monitor Closely. Lessen nightly dose of lemborexant advisable if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.
zafirlukast will increase the stage or influence of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Reactivation of herpes zoster: Patients taken care of with bortezomib have to be managed with antiviral prophylaxis as reactivation of herpes zoster is an actual likelihood.
Watch Intently (1)lenacapavir will boost the amount or result Imidacloprid of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
You must deliver this record along with you each time you stop by a physician AXL-IN-13 or In case you are admitted to some healthcare facility. It is additionally critical info to hold with you in the event of emergencies.
Speak to your health practitioner about taking in grapefruit and ingesting grapefruit juice whilst employing this medication.
crizotinib boosts amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction may be wanted for coadministered medicines that are predominantly metabolized by CYP3A.